Orun, IbrahimTalas, Zeliha SelamogluAlkan, Aysel2024-08-042024-08-0420111018-46191610-2304https://hdl.handle.net/11616/103707The present study was performed to understand the preventive effect of selenium (Se4+) on heavy metal stress induced by Cd2+ and Cr3+ in rainbow trout. Changes in glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD) activity, and in malondialdehyde (MDA) level in gill tissue of rainbow trout after 7 days of exposure to Cd2+ and Cr3+ were investigated in the presence and absence of Se4+. Heavy metals treated groups exhibited significant decreases (P<0.05) in GSH-Px, CAT, SOD activities of gill, and an increase (P<0.05) in MDA levels, compared to the control. In the presence of Se4+, GSH-Px activity and SOD activity were found to be higher and MDA levels were lower compared with in its absence. In the light of our findings, it could be stated that Cd2+ and Cr3+ lead to dramatic changes in biochemical parameters and selenium caused these parameters to converge to control levels when it was administered concurrently with these heavy metals. Selenium fully or partially restored enzyme activities. Lipid peroxidation was also decreased in selenium treated groups.eninfo:eu-repo/semantics/closedAccessAntioxidant enzymesgillsheavy metalslipid peroxidationrainbow troutoxidative stressseleniumArticle201104108WOS:000288302800014Q4