Ataman, EnginHarputluoglu, MuratCarr, Brian IrvingGozukara, HarikaInce, VolkanYilmaz, Sezai2024-08-042024-08-0420241307-58882757-7392https://doi.org/10.14744/hf.2023.2023.0038https://hdl.handle.net/11616/102075Background and Aim: Several tumor and non-tumor factors affect the prognosis of hepatocellular carcinoma (HCC) patients. This study aimed to investigate the effects of hepatitis B virus (HBV) viral load on tumor and non-tumor factors in patients with HBV-associated HCC. Materials and Methods: Patients with hepatitis B and HCC who presented Transplantation Institute, were included in our study. Patients were divided into two groups according to the presence or absence of HBV-DNA, and it was determined whether there were differences between these two groups with respect to tumor and non-tumor parameters. Results: Comparison of serum alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), hepatitis B surface antigen (HBsAg), and C-reactive protein (CRP) levels between HBV-DNA negative and positive patients showed significant differences (respectively p<0.01, p<0.01, p<0.05, and p<0.05). A major finding was a very significant difference between the two patient groups in terms of portal vein invasion (PVI) and venous invasion (p<0.001 and p<0.01, respectively). However, there was no significant difference in metastasis or lymph node involvement between HBV-DNA negative and positive patients. Conclusion: Our findings suggest that HBV viral load plays an important role in PVI in HCC patients, and there is a significant relationship between HBV viral load and inflammation.eninfo:eu-repo/semantics/openAccessHepatitis Bhepatocellular carcinomaHBV-DNAArticle5273763848773810.14744/hf.2023.2023.00382-s2.0-85196706859N/AWOS:001182619800004N/A