Dogan, HacerBahar, Mehmet RefikCaliskan, ErayTekin, SuatUslu, HarunAkman, FerideKoran, Kenan2024-08-042024-08-0420220739-11021538-0254https://doi.org/10.1080/07391102.2020.1846621https://hdl.handle.net/11616/99633The hexachlorocyclotriphosphaze compound (N3P3Cl6, HCCP) was reacted with excess (E)-(1-(4 '-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-ones (2-11) to produce hexakis[(1-(4-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-one)]cyclotriphosphazenes (CP 2-11). The structures of products (CP 2-11) were confirmed using elemental analysis, FT-IR, MS spectral analysis as well as P-31, H-1 and C-13-APT NMR techniques and their thermal properties determined by TGA and DSC techniques. The HOMO-LUMO energy gap and chemical reactivity identifiers were calculated and HOMO and LUMO images were viewed. According to the calculations, all the chemical potential values of CP 2-11 are negative and it shown that the molecules are stable. The in vitro cytotoxic of CP 2-11 investigated and their activity potentials were evaluated by molecular docking studies with Autodock Vina softwares. CP 2-11 compounds were found to demonstrate cytotoxic activity against human cancer cell lines (A2780, LNCaP and PC-3). The CP 2-11 compounds reduced the cell viability against all cancer cell lines in the range 36%-90% especially. The results showed that these compounds are powerful candidate molecules for pharmaceutical applications.eninfo:eu-repo/semantics/closedAccessMTT assayspiro-phosphazenecytotoxicitymolecular dockingstructural characterizationsArticle407325832723321056010.1080/07391102.2020.18466212-s2.0-85096315080Q2WOS:000590376800001N/A