Ara, CengizEşrefoğlu, MukaddesPolat, AlaadinIşık, BurakAladağ, MuratGül, MehmetAy, SelmaTekerekoğlu, M.SaitYılmaz, Sezai2018-02-092018-02-092006Ara, C., Eşrefoğlu, M., Polat, A., Işık, B., Aladağ, M., Gül, M., … Tekerekoğlu, M. S. (2006). The Effect Of Caffeic Acid Phenethyl Ester On Bacterial Translocation And İntestinal Damage İn Cholestatic Rats. Dig Dis Sci, 0–0.https://link.springer.com/content/pdf/10.1007%2Fs10620-006-9130-4.pdfhttps://hdl.handle.net/11616/8067Dig Dis Sci (2006) 51:1754–1760.We investigated the effect of caffeic acid phenethyl ester in rat ileum injury induced by chronic biliary obstruction. Swiss albino rats were divided into three groups: Group 1, sham (n = 7); Group 2, common bile duct ligation (n = 7); and Group 3, common bile duct ligation plus caffeic acid phenethyl ester (n = 7). In the caffeic acid phenethyl ester-treated rats, ileum tissue levels of malondialdehyde and myeloperoxidase were significantly lower than those of the bile duct-ligated rats (P < 0.001). The levels of tumor necrosis factor-α, interleukin-6, and interleukin-1α in the caffeic acid phenethyl ester group were significantly lower than those in the bile duct ligation group (P < 0.03, P < 0.01, and P < 0.02 respectively). The present study demonstrates that intraperitoneal administration of caffeic acid phenethyl ester in bile duct-ligated rats reduces intestinal oxidative stress. This effect may be useful in the preservation of intestinal damage in cholestasis.eninfo:eu-repo/semantics/openAccessArticle51017541760