Elmas, A. T.Karadag, A.Tabel, Y.Ozdemir, R.Otlu, G.2024-08-042024-08-0420171476-70581476-4954https://doi.org/10.3109/14767058.2016.1171311https://hdl.handle.net/11616/97292Objective: We designed the present study to test the hypothesis that urinary biomarkers might predict acute kidney injury (AKI) development in non-septic and non-asphyxiated critically ill preterm infants. We evaluated urine (u) sistatin-C (uCys-C), kidney injury molecule-1 (uKIM-1) and neutrophil gelatinase associate lipocaline (uNGAL) as markers of AKI. Methods: Sixty-four preterm infants with gestational age between 28 and 32 weeks were included in this study. Biomarkers were measured on day of life (DOL) 1, 3, and 7. Results: uNGAL levels in the AKI group were significantly higher than in no-AKI group on DOL 1, 3 and 7 (p = 0.016, p = 0.007 and p = 0.0014, respectively). Conclusions: uNGAL is sensitive, early, and noninvasive AKI biomarkers, increasing significantly in non-septic and non-asphyxiated critically ill preterm neonates.eninfo:eu-repo/semantics/closedAccessAcute kidney injurykidney injury molecule-1neutrophil gelatinase associate lipocalinepreterm infantssistatin-CurineArticle3033023082702037210.3109/14767058.2016.11713112-s2.0-84964489965Q2WOS:000389664200011Q4