Harputluoglu, Murat Muhsin MuhipTemel, IsmailDemirel, UlviSeckin, YukselAladag, MuratOtlu, BarisKaradag, Nese2024-08-042024-08-0420171300-49482148-5607https://doi.org/10.5152/tjg.2017.1775https://search.trdizin.gov.tr/yayin/detay/232859https://hdl.handle.net/11616/92482Background/Aims: Steroids have been shown to prevent intestinal oxidative stress. We investigated the effects of methylprednisolone on intestinal oxidative damage and bacterial translocation in thioacetamide-induced liver failure in rats. Materials and Methods: Group 1 (n=8) was the control group. In group 2 (n=8), the thioacetamide group, rats received 300 mg/kg intraperitoneal thioacetamide daily for 2 days. In group 3 (n=8), the thioacetami de+methylprednisolone group, treatment with methylprednisolone (30 mg/kg intraperitoneal) was commenced 48 h before the first dose of thioacetamide. In group 4 (n=8), the methylprednisolone group, the rats received only methylprednisolone (30 mg/kg intraperitoneal). Results: Serious hepatic and intestinal oxidative damage and high bacterial translocation frequencies were observed in the thioacetamide group compared with those of the controls. Bacterial translocation frequency in the thioacetamide+methylprednisolone group was significantly lower than that in the thioacetamide group (p<0.05). Intestinal thiobarbituric acid-reactive substances and myeloperoxidase levels and tissue damage scores for the intestines in the thioacetamide+methylprednisolone group were lower than those in the thioacetamide group (p<0.01, p<0.01, and p<0.0001, respectively). Conclusion: Our findings suggest that methylprednisolone reduces bacterial translocation by preventing intestinal oxidative damage in this model of acute liver failure in rats.eninfo:eu-repo/semantics/closedAccessMethylprednisoloneliver failurebacterial translocationArticle2853944002877649810.5152/tjg.2017.17752-s2.0-85029789622Q3232859WOS:000411468300012Q4