Akyol Ö.Ünal S.2024-08-042024-08-0420031017-7833https://hdl.handle.net/11616/90858Information in the brain is transmits by both synaptic and nonsynaptic neurotransmission (NSN). NSN includes the diffusion through the extracellular fluid of neurotransmitters released from nonsynaptic varicosities and high-affinity transmitter receptors and transporters. This high-affinity uptake system is the target of many neurotransmitters such as noradrenaline, dopamine, serotonin, acetylcholine and nitric oxide (NO) and also many drugs such as tricyclic antidepressants, psychostimulants serotonin reuptake blockers, and anticonvulsants. NSN also includes the diffusion of substances such as NO and carbon monoxide (CO) through both extracellular fluid and cellular membranes. It has been shown that NO can influence the function of uptake carrier systems. In this paper, the possible roles of NSN in the brain activity and drug actions are reviewed.trinfo:eu-repo/semantics/closedAccessNitric oxideNonsynaptic neurotransmissionVolume transmissionReview Article1341972032-s2.0-0842264231N/A