Tanbek, KevserYilmaz, UmitGul, MehmetKoc, AhmetSandal, Suleyman2024-08-042024-08-0420231381-34551744-4160https://doi.org/10.1080/13813455.2023.2166964https://hdl.handle.net/11616/101120IntroductionGlucose homeostasis is a physiological process mediated by a variety of hormones. Fibroblast growth factor (FGF) 21 is a protein expressed in the liver, adipose tissue, muscle and pancreas and exerts actions in multiple targets including adipose, liver, pancreas and hypothalamus. The aim of this study was to examine the possible involvement of FGF21 in pancreatic and central control of glucose by measuring reflective changes in the release of insulin and glucagon.MethodsThirty adult male Wistar Albino rats were divided; Control, PD + aCSF, PD + FGF21 groups (n = 10). Effects of intracerebroventricular (icv) FGF21 administration to pancreatic denervated (PD) rats. Agouti-related protein (AgRP), Pro-opiomelanocortin (POMC) levels and blood glucose homeostasis were investigated.ResultsAdministration of FGF21 to 3rd ventricle increased food consumption but body weight didn't change significantly. AgRP level increased, pancreatic insulin levels increased, and glucagon level decreased.ConclusionCentral FGF21 administration is effective in regulating blood glucose homeostasis by increasing the amount and efficiency of insulin and changing glucose use.eninfo:eu-repo/semantics/closedAccessGlucose homeostasisFGF21insulinglucagonpancreatic denervationAgRPPOMCArticle3664539610.1080/13813455.2023.21669642-s2.0-85146344658Q2WOS:000913132000001Q2