Mertoglu, CumaSiranli, GulsahCoban, T. AbdulkadirKarakurt, YucelErsoy, AlevtinaOzcicek, AdaletArslan, Yusuf2024-08-042024-08-0420212148-49022536-4553https://doi.org/10.14744/nci.2021.33341https://search.trdizin.gov.tr/yayin/detay/508452https://hdl.handle.net/11616/92869OBJECTIVE: The role of protein oxidation in the development of diabetic microvascular complications was investigated. METHODS: In total, 266 participants were split into five groups: Group 1; diabetes mellitus for at least 10 years without any complications, Group 2; diabetic nephropathy, Group 3; diabetic neuropathy, Group 4; diabetic retinopathy, and Group 5; control group. Thiol, disulfide, ferroxidase, and ischemia-modified albumin (IMA) levels were analyzed in the serum. RESULTS: Native thiol, total thiol, and native thiol/total thiol were lower in Group 4 than Groups 1, 3, and 5 (p<0.001). However, disulfide/native thiol and disulfide/total thiol were higher in Group 4 than all other groups (p<0.001). IMA was higher in Groups 3 and 4 than all other groups (p<0.001). Ferroxidase was lower in Groups 3 and 4 than Group 2 (p<0.001). CONCLUSION: Thiol-disulfide homeostasis impairment in favor of disulfide may have a function in the progress of diabetic retinopathy. Furthermore, the disruptions of IMA and ferroxidase levels involve in the development of diabetic retinopathy and neuropathy.eninfo:eu-repo/semantics/openAccessDiabetes mellitusmicrovascular complicationsneuropathyretinopathythiol-disulfideArticle855005063490958910.14744/nci.2021.33341508452WOS:000714065600010N/A