Kapicioglu, YeldaGul, MehmetSarac, GulbaharYigitcan, BirgulGozukara, Harika2024-08-042024-08-0420191076-05121524-4725https://doi.org/10.1097/DSS.0000000000001717https://hdl.handle.net/11616/98715BACKGROUND Polydioxanone Cog thread and poly-L-lactic acid (PLLA) thread have been used clinically for lifting and antiaging purposes. However, the histological changes in tissue and the efficacy of these 2 different types of thread have not been compared. OBJECTIVE This study used hematoxylin and eosin (H&E) staining, Masson's trichrome staining, and electron microscopy (EM) to compare the results associated with the use of Cog thread and PLLA thread in rat skin. METHODS Thirty female rats were divided into 3 groups of 10 rats each: a control group; a Cog group; and a PLLA group. Biopsy specimens obtained at 1, 3, and 6 months were examined using H&E, MT, and EM. RESULTS Although significant increases were observed in dermal thickness and the numbers of fibroblasts in the PLLA group compared with the control group within the first month (p: .019), there were no significant differences between the Cog and control groups during this period (p: .245). Dermal thickness (p: .002) and numbers of fibroblasts (p: .001) were similar in samples obtained from the PLLA and Cog groups at 3 and 6 months, and both groups showed significantly improved outcomes compared with the control group. CONCLUSION Poly-L-lactic acid and Cog sutures were effective in facial rejuvenation; both increased dermis thickness and stimulated collagen production.eninfo:eu-repo/semantics/closedAccessPolydioxanoneArticle4534384453060829410.1097/DSS.00000000000017172-s2.0-85062693593Q2WOS:000462415600014Q2