Korkmaz, Mehmet FatihParlakpinar, HakanErdem, Mehmet NuriCeylan, Mehmet FethiEdiz, LeventSamdanci, EmineKekilli, Ersoy2024-08-042024-08-0420200268-86971360-046Xhttps://doi.org/10.1080/02688697.2020.1749984https://hdl.handle.net/11616/99256Objective: The aim of this study was to evaluate histopathological, functional and bone densitometry examinations of the beneficial effects of dexpanthenol (DEX) on nerve regeneration in a rat model of peripheral nerve crush injury. Methods: Thirty adult Sprague-Dawley rats were divided equally into three groups. A crush injury was simulated in all rats by clamping the right sciatic nerve for one minute. In group 1, one day before the surgical procedure, 500 mg/kg DEX administered via intraperitoneally (ip) was initiated and continued three times in a week during the experiment period as 28 days. In group 2, rats received a dose of 10 mg/kg DEX to investigate possible effects of DEX alone. Group 3 served as the control (sciatic nerve injury) and was not given any drugs. Results: Performance was significantly lower in group 3 compared to the drug treatment groups during the rotarod test (30 rpm and 40 rpm) (p < 0.05). After a while, the rats which were able to remain on the rod was significantly lower in group 3 during the acceleration test (p < 0.05). Hot plate latency test results in group 3 were significantly lower when compared to the other groups (p < 0.05). Conclusion: DEX appears to be useful as a supportive clinical agent for the treatment of pain and nerve damage.eninfo:eu-repo/semantics/closedAccessBone mineral densitydexpanthenolperipheral nerve traumastatic sciatic indexArticle3443974013229752510.1080/02688697.2020.17499842-s2.0-85083672906Q3WOS:000527707200001Q4