Yeşilkaya, EdizBereket, AbdullahDarendeliler, FeyzaBaş, Firdevs2017-07-092017-07-092015EDİZ, Y., BEREKET, A., DARENDELİLER, F. F., BAŞ, F., POYRAZOĞLU, Ş., BANU, K., … AKINCI, A. (2015). Turner Syndrome and Associated Problems in Turkish Children A Multicenter Study. Journal of Clinical Research in Pediatric Endocrinology, 7(1), 27–36.http://cms.galenos.com.tr/FileIssue/1/793/article/27-36.pdfhttps://hdl.handle.net/11616/7325J Clin Res Pediatr Endocrinol 2015;7(1):27-36Turner syndrome (TS) is a genetic disorder characterized by total or partial absence of one sex chromosome (1). It is one of the most common chromosomal disorder with an incidence of 1:2500 female live births (2,3). The most prevalent karyotype is 45,X, followed by mosaic patterns. TS is associated with several morbidities that increase with age. Although TS causes several multisystem disorders, the most common presentation is usually due to short stature and primary gonadal deficiency. Patients may present with congenital malformations such as horseshoe kidney and coarctation of the aorta. They may also develop diabetes, hypothyroidism, hypertension, hearing loss, osteoporosis and bone fractures (4,5). Timely diagnosis and proper management of associated problems may reduce substantial morbidity and mortality and improve the quality of life in TS patients. Studies based on a large pediatric population which provide data on frequency of associated problems and their distribution among the different karyotypes are scarce (6,7,8). In the present study, we aimed to define the frequency of associated problems in TS patients during childhood and the distribution of these clinical features according to karyotype and age by evaluating 842 patients with TS from 35 centers in Turkeyeninfo:eu-repo/semantics/openAccessNationwide studyTurner syndromeChildrenDiagnostic featuresAssociated problemsArticle71273610.4274/jcrpe.1771