Akkoc, MitatBalcioglu, SevgiGurses, CanbolatTok, Tugba TaskinAtes, BurhanYasar, Sedat2024-08-042024-08-0420180022-328X1872-8561https://doi.org/10.1016/j.jorganchem.2018.06.003https://hdl.handle.net/11616/98329New benzimidazolium salts 1a-d having methylpyridine group on the side chain, have been synthesized and reacted with Ag2O to produce Ag(I)-N-heterocyclic carbene (NHC) complexes 2a-d. Ag(I)-N-heterocyclic carbene (NHC) complexes were used as a carben transfer agents to synthesize water-soluble ruthenium(II)-NHC complexes 4a-d. All synthesized compounds were fully characterized by H-1 and C-13 NMR and HRMS spectroscopic techniques. Anticancer potential and IC50 values of ruthenium(II)-NHC complexes were evaluated by MTT assay against human colorectal cancer (Caco-2) and breast cancer (MCF-7) cell lines. The IC50 value of water-soluble ruthenium(II)-NHC complex 4d demonstrated remarkable cytotoxic activity against Caco-2 (18.0 +/- 1) and MCF-7 (23.8 +/- 0.5) cell lines. Also, 4d has better DNA binding capacity than 4a-c. DS 2017 R2 was used to exert molecular docking for understanding interactions between the water-soluble ruthenium(II)-NHC complexes and DNA. These complexes have been highlighted as a new type of drug. (C) 2018 Elsevier B.V. All rights reserved.eninfo:eu-repo/semantics/closedAccessAnticancer activityDNA bindingN-heterocyclic carbeneRutheniumWater soluble complexArticle869677410.1016/j.jorganchem.2018.06.0032-s2.0-85048262138Q3WOS:000437721800008Q3