Behcet, AytenCaglilar, TubaCelepci, Duygu BarutAktas, AydinTaslimi, ParhamGok, YetkinAygun, Muhittin2024-08-042024-08-0420180022-28601872-8014https://doi.org/10.1016/j.molstruc.2018.05.077https://hdl.handle.net/11616/98317This paper reports the synthesis of 2-(4-hydroxyphenyl)ethyl and 2-(4-nitrophenyl)ethyl substituted benzimidazolium salts. The benzimidazolium salts were synthesized by N-substituted benzimidazolium and aryl halides. The 2-(4-hydroxyphenyl)ethyl and 2-(4-nitrophenyl)ethyl substituted benzimidazolium salts were characterized by using H-1 NMR, C-13 NMR, FT-IR spectroscopy and elemental analysis techniques. Molecular and crystal structure of the complex 2d and 3d were obtained by single-crystal X-ray diffraction method. Additionally, The enzyme inhibition activities of the benzimidazolium salts were investigated. These 2-(4-hydroxyphenyl)ethyl and 2-(4-nitrophenyl)ethyl substituted benzimidazolium salts (1, 2a-g, and 3a-f) showed good inhibitory action against acetylcholinesterase (AChE), and human (h) carbonic anhydrase (CA) isoforms I, and II. Ki values for AChE were in range of 5.97 +/- 0.56 -23.15 +/- 3.98 nM. On the other hand, the hCA I, and II isoenzymes were effectively inhibited by these compounds, with K-i values in the range of 17.33 +/- 4.55-99.23 +/- 44.91 nM for hCA I, and 33.98 +/- 3.43 -113.23 +/- 39.31 nM for hCA II, respectively. (C) 2018 Elsevier B.V. All rights reserved.eninfo:eu-repo/semantics/closedAccessN-heterocyclic carbenes precursorsBenzimidazoleSingle-crystal X-ray diffractionCarbonic anhydraseAcetylcholinesteraseEnzyme inhibitionArticle117016016910.1016/j.molstruc.2018.05.0772-s2.0-85047992294Q2WOS:000437071000018Q3