Alkan, AlpayKutlu, RamazanTarık, HallaçSığırcı, AhmetEmul, MuratPala, NilgünAltınok, TayfunAslan, MehmetSaraç, KayaÖzcan, Abdulcemal2017-05-222017-05-222004Alkan, A. Kutlu, R. Tarık, H. Sığırcı, A. Emul, M. Pala, N. Altınok, T. Aslan, M. Saraç, K. Özcan, A. (2004). Occupational prolonged organic solvent exposure in shoemakers brain MR spectroscopy findings. Magnetic Resonance Imaging, 22(5), 707–713.0730725Xhttp://linkinghub.elsevier.com/retrieve/pii/S0730725X04001092https://hdl.handle.net/11616/6928Our purpose was to investigate, by magnetic resonance (MR) spectroscopy, the metabolite changes in the brains of subjects in the shoemaking industry who had been chronically exposed to organic solvents. A total of 49 male subjects and 30 age-matched healthy volunteers underwent detailed neurological and psychiatric examinations. All subjects had long-echo [repetition time (TR) 2000 ms, echo time (TE) 136 ms] single-voxel MR spectroscopy. Voxels (15 15 15 mm3 ) were placed in the parietal white matter, thalamus, and basal ganglia. N-acetylaspartate (NAA)/creatine (Cr) and choline (Cho)/Cr ratios were calculated. There was no significant difference between the study subjects and the control group in NAA/Cr ratios obtained from thalamus, basal ganglia, and parietal white matter. Cho/Cr ratios in thalamus, basal ganglia, and parietal white matter were found to be significantly increased compared to controls. There was a positive correlation between basal ganglia Cho/Cr ratio and duration of exposure (r 0.63). MR spectroscopy should be performed to reveal metabolite changes and determine the degree of brain involvement in solvent-related industry workers.eninfo:eu-repo/semantics/openAccessOccupational exposureSolventsMagnetic resonance spectroscopyArticle22570771310.1016/j.mri.2004.01.070