Akatli, Ayse NurSamdanci, EmineCelik, Muhammet RehaAlan, SaadetUlutas, HakkiAkpolat, Nusret2024-08-042024-08-0420221022-386X1681-7168https://doi.org/10.29271/jcpsp.2022.JCPSPCR.CR197https://hdl.handle.net/11616/101092Primary thymic seminoma is an exceedingly rare tumour. There are few case reports about mediastinal thymic seminoma accompanied by secondary changes. We report a case of a 29-year male admitted to our hospital because of chest pain and dyspnea for 8 months. Computed tomography of the thorax revealed hypodense, solid masses showing calcification and cystic degeneration in the anterior mediastinum. Histopathological examination of the resected specimen revealed a diagnosis of thymic seminoma with regressive and reactive changes. The present case was unique in its presentation as a primary seminoma showing combination of cystic degeneration, follicular hyperplasia, fibrosis, calcification and granulomatous reaction in one case. High level of suspicion is necessary to identify seminomas in a thymic lesion accompanied by secondary changes. Excluding the possibility of metastasis from testicular seminoma is very important before making this diagnosis.eninfo:eu-repo/semantics/closedAccessThymusSeminomaGranulomaCalcificationCystArticle3219719910.29271/jcpsp.2022.JCPSPCR.CR1972-s2.0-85145431069Q3WOS:000943650300034Q4