Altinkaynak, SevinSelimoglu, Mukadder AyseTurgut, AhmetKilicaslan, BuketErtekin, Vildan2024-08-042024-08-0420060277-21161536-4801https://doi.org/10.1097/01.mpg.0000215309.93911.84https://hdl.handle.net/11616/94395Objectives: Whether breast-feeding is associated with decreased incidence of the lymphoid malignancies in children is uncertain. We evaluated childhood acute leukemia and lymphoma in relation to duration of breast-feeding. Methods: We investigated this issue in a case-control study comprising 137 patients, aged I to 16 years, with acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), Hodgkin or non-Hodgkin lymphoma, in addition to 146 controls matched for age and sex. Results: The median duration of breast-feeding among patients was shorter than that of controls (10 vs 12 months). Patients with ALL and AML had shorter mean breast-feeding duration compared with healthy children (P = 0.001 and P < 0.001, respectively). The shortest mean breast-feeding duration was noted in the children with AML. Breast-feeding for a duration of 0 to 6 months, when compared with feeding of longer than 6 months, was associated with increased odds ratios (ORs) for ALL [OR = 2.44, 95% confidence interval (Cl) = 1.17-5.101, AML (OR = 6.67 95% Cl = 1.32-33.69), Hodgkin lymphoma (OR 3.33, 95% Cl = 0.60-18.54), non-Hodgkin lymphoma (OR 1.90, 95% Cl = 0.68-5.34) and overall (OR = 2.54, 95% Cl = 1.51-4.26). Conclusions: Our findings suggest that breast-feeding of more than 6 months is protective against childhood lymphoid malignancies, especially for AML and ALL.eninfo:eu-repo/semantics/openAccessbreast-feedingacute lymphocytic leukemiaacute myeloid leukemiahodgkin lymphomanon-Hodgkin lymphomaArticle4255685721670798210.1097/01.mpg.0000215309.93911.842-s2.0-33744461554Q1WOS:000237530800018Q1