Alkan, AlpayKutlu, RamazanKoçak, GülendamSığırcı, AhmetEmul, MuratDoğan, SeldaAslan, MehmetSaraç, KayaYakıncı, Mehmet Cengiz2017-06-232017-06-232004Alkan, A. Kutlu, R. Koçak, G. Sığırcı, A. Emul, M. Doğan, S. Aslan, M. Saraç, K. Yakıncı, M. C. (2004). Brain MR spectroscopy in children with a history of rheumatic fever with a special emphasis on neuropsychiatric complications. Eur J Radiol. 49; 224-228.https://hdl.handle.net/11616/7165Purpose: To investigate whether there are metabolite changes in basal ganglia of children with complete healing of rheumatic fever (RF), history of Syndenham chorea (SC) and obsessive compulsive-tic disorder (OCTD) developed after RF when compared with healthy controls and each other. Material and methods: A total of 49 children with history of RF and 31 healthy controls were included into the study. All patients and control group underwent a detailed neuropsychiatric evaluation. Children with the history of RF were classified into three groups as; group 1: with history of RF without neuropsychiatric complications (NCRF), group 2: only with history of SC (HSC), group 3: with HSC and OCTD (OCTD). After MR imaging, single voxel MR spectroscopy was performed in all subjects. Voxels (15 × 15 × 15 mm) were placed in basal ganglia. N-acetyl aspartate (NAA)/creatin (Cr), and choline (Cho)/Cr ratios were calculated. Results: OCTD were detected in 13 children with HSC. NAA/Cr ratio was found to be decreased in these children when compared with NCRF (n:29), HSC without OCTD (n:7) and control groups (n:31). No significant difference was found in metabolite ratios of children with HSC without OCTD when compared with NCRF and control groups. There were no significant differences in Cho/Cr ratio between patient and control groups. Conclusion: Although MR imaging findings was normal, MR spectroscopy findings (decreased NAA/Cr ratio) in our study support the neuronal loss in basal ganglia of children with OCTD and could indicate the development of permanent damage.eninfo:eu-repo/semantics/openAccessRheumatic feverChoreaObsessive compulsive disorderMagnetic resonance spectroscopyArticle4922422810.1016/S0720-048X(03)00177-3