Demirbilek, SKaraman, AGürünlüoglu, KTas, EAkin, MAksoy, RTTürkinen, E2024-08-042024-08-0420061386-6346https://doi.org/10.1016/j.hepres.2005.09.040https://hdl.handle.net/11616/94242Background: Hepatic injury induced by ischemia/reperfusion following surgery, transplantation, or circulatory shock combined with resuscitation is a major clinical problem. Polyenylphosphatidylcholine (PPC) has strong antioxidant, cytoprotective and anti-inflammatory effects. Aim: In this study, the influence of PPC pretreatment on ischemia-reperfusion (I/R) injury of the liver was examined in rats. Methods: The animals were divided into three groups: control (n = 10), I/R (n = 15) and IIR + PPC (n = 15). PPC was given 100 mg/day for 7 days before experiment. Several parameters of hepatic damage, oxidative stress, neutrophil infiltration and nuclear factor kappa beta (NF-kappa B) expression were measured as well as microscopic examination. Results: We observed that a significant reduction in AST and ALT values in the PPC treated group when compared with the ischemic group. The increases in hepatic total NO2 + NO3 and MDA, and decreases in SOD and GSH levels after reperfusion were partially, but significantly, inhibited by PPC pretreatment. I/R induced increase in hepatic myeloperoxidase content and NF-kappa B expression were also lowered by PPC pretreatment. Animals pretreated with PPC presented minimal hemorrhage and reduced signs of liver injury. Conclusion: PPC pretretament provided significant protection againts I/R injury to the liver. This treatment could be therapeutic in liver transplantation and other conditions associated with I/R injury. (c) 2005 Elsevier Ireland Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessliver ischemia/reperfusionoxidative stresspolyenylphosphatidylcholinelecithinhepatic ischemia/reperfusionArticle34284911640679410.1016/j.hepres.2005.09.0402-s2.0-31344448765Q1WOS:000235502800004Q4