Gulcan, HKuzucu, CDurmaz, R2024-08-042024-08-0420040196-65531527-3296https://doi.org/10.1016/j.ajic.2004.07.003https://hdl.handle.net/11616/94663Background: Increased nosocomial Stenotrophomonas maltophilia infection rates in newborns, especially in recent years, are a significant cause for concern. These cases are the second case group in the literature to have been identified as nosocomial cross-infection with S maltophilia in neonates. Objective: To investigate the clinical, microbiological, and epidemiologic features of the outbreak caused by S maltophilia in the neonatal intensive care unit within a period of 7 days. Methods: Three cases with nosocomial S maltophilia infection considered to be the result of cross-transmission were prospectively analyzed. Arbitrarily primed polymerase chain reaction (AP-PCR) performed with M13 primer and pulsed-field gel electrophoresis (PFGE) of genomic DNA after digestion with XbaI were used to determine clonal relationship among the isolates. Results: S maltophilia was isolated from the blood cultures of all 3 patients. Molecular typing confirmed that the 3 cases were epidemiologically linked. Conclusions: Opportunistic pathogens such as S maltophila can lead to major problems in neonates. Molecular typing is helpful to improve effective control programs for preventing the spread of the infection.eninfo:eu-repo/semantics/closedAccess[No Keywords]Article3263653681545489710.1016/j.ajic.2004.07.0032-s2.0-5344241197Q1WOS:000224352800010Q2