Tanrikut, E.Karaer, A.Celik, O.Celik, E.Otlu, B.Yilmaz, E.Ozgul, O.2024-08-042024-08-0420140301-21151872-7654https://doi.org/10.1016/j.ejogrb.2014.05.039https://hdl.handle.net/11616/96510Objective: To determine the role of endometrial concentrations of heavy metals (cadmium, lead, mercury and arsenic) in the aetiology of unexplained infertility. Study design: Thirty-three women with unexplained infertility and 32 fertile women were recruited. Endometrial biopsies were collected during the putative window of implantation (cycle days 20-24). The concentrations of cadmium, lead, mercury and arsenic were measured in endometrial biopsy specimens using atomic absorption spectrometry. Results: Cadmium was detected in 91% (30/33) of women with unexplained infertility, compared with 34% (11/32) of fertile women. The median endometrial cadmium concentration was 19.58 (interquartile range 1.46-30.23) mu g/l in women with unexplained infertility, compared with 0.00 (interquartile range 0.00-0.40) mu g/l in fertile women. Lead was detected in 15% (5/33) of women with unexplained infertility and 3% (1/32) of fertile women. Mercury and arsenic were not detected in any endometrial samples from either group. Conclusion: A significant difference in endometrial cadmium concentration was found between women with unexplained infertility and fertile women. This suggests that cadmium may be a contributing factor in the aetiology of unexplained infertility. (C) 2014 Elsevier Ireland Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessArsenicCadmiumLeadMercuryUnexplained infertilityArticle1791871902496600010.1016/j.ejogrb.2014.05.0392-s2.0-84904615857N/AWOS:000340318200035Q3