Yildir, MerveGenc, Asena AyseBugday, NesrinErk, NevinPeighambardoust, Naeimeh SadatAydemir, UmutYasar, Sedat2026-04-042026-04-0420242470-1343https://doi.org/10.1021/acsomega.4c05505https://hdl.handle.net/11616/109362A novel composite containing CoS and nitrogen-doped amorphous porous carbon (NAPC), denoted as CoS@NAPC, was successfully synthesized from a mixture of cobalt-based ZIF-12 and sulfur through one-pot pyrolysis. The morphology and microstructure of the composites are evaluated with appropriate spectroscopic techniques. CoS@NAPC was used to modify the glassy carbon electrode (GCE) to detect Nilotinib. Under optimized conditions, the GCE electrode modified with CoS@NAPC showed a low limit of detection (LOD) of 11.8 ng/mL and two wide linear concentration ranges of 59.7-1570 and 1570-11200 ng/mL for the determination of Nilotinib. GCE electrode modified with CoS@NAPC has excellent recoveries ranging from 98.41 to 102.03% for real samples, demonstrating its superior analytical performance. The enhanced performance of CoS@NAPC as an electrochemical sensor may stem from the combined action of two key components: CoS, known for its potent reactivity toward Nilotinib, and NAPC, which offers a consistent conductive carbon matrix. CoS contributes to its reactivity, while NAPC facilitates electron transfer during Nilotinib detection. This synergistic effect likely underlies the superior sensor performance observed.eninfo:eu-repo/semantics/openAccessPerformance Liquid-ChromatographyTyrosine Kinase InhibitorsFormation MechanismImatinibNanoparticlesElectrodesLithiumUrineNanohybridsBiosensorsArticle1012612713982957610.1021/acsomega.4c055052-s2.0-85214997033Q1WOS:001387418800001Q20000-0002-2991-54880000-0001-5366-92750000-0001-7285-2761