Cumurcu, TongabayGunduz, AbuzerCumurcu, Birgul ElbozanGul, Isil GogcegozAkpolat, NusretKarlidag, Rifat2024-08-042024-08-0420130277-37401536-4798https://doi.org/10.1097/ICO.0b013e31825239d1https://hdl.handle.net/11616/95958Purpose: To evaluate the tear film function and ocular surface changes in heavily drinking men. Methods: This prospective case-control study involved 35 male subjects with heavy alcohol consumption (group 1) and 35 age-and sex-matched control subjects (group 2). Best-corrected visual acuity measurement, slit-lamp examination, Schirmer I test, tear film break-up time (BUT) measurement, and conjunctival impression cytology were performed in all subjects. The results were compared between the 2 groups. Results: The mean Schirmer I test results in group 1 and group 2 were 8.31 +/- 3.56 mm and 13.17 +/- 5.71 mm, respectively, and the mean BUT values were 9.22 +/- 3.10 seconds and 13.20 +/- 4.04 seconds, respectively. The mean Schirmer I and BUT results were statistically lower in group 1 than in group 2 (P < 0.0001). The mean impression cytology scores in group 1 and group 2 were 2.08 +/- 0.78 and 1.37 +/- 0.94, respectively. A statistically significant difference was noted between the study and control groups for the grading of cytological changes (P = 0.001). Conclusions: Our data showed that heavily drinking men have decreased tear production, tear film instability, and significant degeneration of the ocular surface epithelium when compared with normal subjects.eninfo:eu-repo/semantics/closedAccessheavy alcohol consumptionimpression cytologyocular surfacetear film functionsArticle3232372412258043510.1097/ICO.0b013e31825239d12-s2.0-84873989581Q1WOS:000314818700003Q2