Ilhan, NevinCelik, EbruKumbak, Banu2024-08-042024-08-0420151476-70581476-4954https://doi.org/10.3109/14767058.2014.916674https://hdl.handle.net/11616/96693Objective: Preterm premature rupture of membranes (PPROM) is associated with significant maternal and perinatal morbidity. This study examined maternal oxidative stress in PPROM. Methods: This was a prospective cross-sectional study conducted in a university hospital. A total of 72 pregnant women were recruited into two groups, those with PPROM (38 cases) and those without PPROM (34 controls) matched for gestational age. Plasma interleukin-6, C-reactive protein, vitamins C, E and A, 8-isoprostane, total oxidant status (TOS) and antioxidant status (TAS) were determined for all study participants and the data were compared between the PPROM and control groups. Results: Both case and control groups were comparably matched in age, parity, gestational age and smoking status. There was a significant association between low 8-isoprostane, low vitamin C and high total oxidant status and the occurrence of PPROM (p < 0.001). Conclusions: Plasma vitamin C and 8-isoprostane levels were lower and TOS higher in women with PPROM. Further research is needed to identify robust biological markers for the prevention and also prognosis of PPROM.eninfo:eu-repo/semantics/closedAccess8-isoprostaneearly membrane ruptureoxidative stresspregnancypreterm premature rupture of membranestotal antioxidant statustotal oxidant statusvitamin CArticle2833163192474979510.3109/14767058.2014.9166742-s2.0-84923320590Q2WOS:000350021100015Q3