Kocak, AKilic, ANurlu, GKonan, AKilinc, KCirak, BColak, A2024-08-042024-08-0419971016-22911423-0305https://doi.org/10.1159/000121176https://hdl.handle.net/11616/93055In order to investigate the pathophysiology of the tethered cord syndrome, a few experimental models have been developed and used previously. In this study, the authors present a new experimental model to investigate the biochemical, electrophysiological, and histopathological changes in the tethered spinal cord syndrome. A model was produced in guinea pigs using an application of cyanoacrylate to fixate the filum terminale and the surrounding tissue to the dorsal aspect of the sacrum following 5-gram stretching of the spinal cord. The experiments were performed on 40 animals divided into two groups. The responses to tethering were evaluated with hypoxanthine and lipid peroxidation, somatosensory and motor evoked potentials, and transmission electron microscope examination. The hypoxanthine and lipid peroxidation levels significantly increased, indicating an ischemic injury (p < 0.01). The average hypoxanthine level in the control group was 478.8 +/- 68.8 nmol/g wet tissue, while ii, was 651.2 +/- 71.5 nmol/g in the tethered cord group, The lipid peroxidation level in group I Nas 64.0 +/- 5.7 nmol/g wet tissue, whereas it Nas 84.0 +/- 4.7 nmol/g in group II. In the tethered cord group, the latencies of the somatosensory and motor evoked potentials significantly increased, and the amplitudes decreased. These changes indicated a defective conduction in the motor and sensorial nerve fibers. In the transmission electron microscopic examinations, besides the reversible changes like edema and destruction in the gray-white matter junction, irreversible changes like scarcity of neurofilaments and destruction in axons and damage in myelin sheaths were observed. We consider that this work can be used as an experimental model for tethered cord syndrome.eninfo:eu-repo/semantics/closedAccesscyanoacrylateevoked potentialsfree radicalsmotor evoked potentialssomatosensory evoked potentialstethered cord syndromeA new model for tethered cord syndrome: A biochemical, electrophysiological, and electron microscopic studyArticle263120126941902810.1159/0001211762-s2.0-0030710227Q3WOS:A1997YJ66500003Q2