Cansel, NeslihanTurkmen, DursunAltunisik, Nihal2024-08-042024-08-0420232148-49022536-4553https://doi.org/10.14744/nci.2021.10170https://search.trdizin.gov.tr/yayin/detay/1165490https://hdl.handle.net/11616/92733OBJECTIVE: Chronic urticaria (CU) is a common skin disease in which the etiology involves immunological and psychological factors. Childhood traumas may disrupt the development of the neuro-immuno-cutaneous-endocrine system and start a complex pathophysiological process with inflammatory abnormalities, potentially leading to the development of skin disease. In light of this information, we believe that childhood trauma may play a role in the onset and severity of disease in CU patients. Our study aimed to discover a potential relationship between CU and childhood traumatic experiences. METHODS: This study was conducted with 53 controls and 50 CU patients. The participants were given a questionnaire form that included sociodemographic information, Beck Anxiety Scale, Beck Depression Scale, and Childhood Trauma Questionnaire (CTQ-28). RESULTS: The rates of childhood trauma were found to be 68% in the patient group, and 54.7% in the control group. The patient group demonstrated higher scores for moderate to severe anxiety and depression. The mean emotional abuse score was significantly higher in early onset (<35 ages) urticaria patients in comparison to late onset urticarial (>= 35 ages) and the control group. It was found that depression scores were positively correlated with all abuse sub-types, excluding sexual abuse, and total CTQ-28 scores. Anxiety scores were positively correlated with emotional abuse, physical neglect, emotional neglect, and total CTQ-28 scores. CONCLUSION: Childhood traumas are associated with the early onset and severity of disease in CU patients as well as the accompanying depression and anxiety.eninfo:eu-repo/semantics/openAccessAnxietychildhood abusechronic urticariadepressionneglectArticle10179863691044410.14744/nci.2021.101702-s2.0-85164599698N/A1165490WOS:000993845400012Q3