Saygin, Aysegul GozeUnal, MuratErcan, NazliDemir, Pinar2024-08-042024-08-0420212667-663Xhttps://doi.org/10.4328/ACAM.20595https://hdl.handle.net/11616/102370Aim: This study aimed to investigate the anti-inflammatory and antioxidant activities of different hemostatic agents and pulp capping materials. Material and Methods: Ninety-six Wistar albino mate rats were divided into the following groups: Sterile Saline (SS), Sodium Hypochlorite (NaOCl), Mecsina Hemostopper (MIAS). Occlusal cavities were prepared in the first molar teeth. Hemostatic agents were used to control bleeding and different pulp capping materials were applied on the exposed pulp area. Subgroups were created according to pulp capping materials (Dycal, Biodentine Theracal, MTA RepairHP). Half of the groups were left to wait for sacrifice on the 7th day and the others on the 28th day. Cardiac blood was taken to determine of antiinflammatory and antioxidant serum markers. Results: The use of different hemostatic agents in terms of antioxidant (CAT, GPX) and anti-inflammatory (IL1-beta, TNF-alpha, IL-6) activity was statistically significant (p <0.05). There was no statistical significance between groups for SOD (p> 0.05). IL-6 was significantly higher on the 7th day than on the 28th day (p <0.05). The and-inflammatory activity reduced from the 7th to the 28th day, in contrast, antioxidant activity induced. Discussion: The inflammation process was related to the hemostatic agents and the capping materials used in DPC treatment. MHS may be an alternative for DPC treatment for bleeding control.eninfo:eu-repo/semantics/openAccessAnti-Inflammatory EffectAntioxidantsDentistryDirect Pulp CappingMecsina HemostopperArticle1237938410.4328/ACAM.20595WOS:000731638200004N/A