Slimani, IchrafChakchouk-Mtibaa, A.Mansour, L.Mellouli, L.Ozdemir, IGurbuzd, NevinHamdi, Naceur2024-08-042024-08-0420201144-05461369-9261https://doi.org/10.1039/d0nj00311ehttps://hdl.handle.net/11616/99246A new series of ruthenium(ii) N-heterocyclic carbene complexes has been synthesized via transmetalation. These complexes are easily handled in very good yields via synthesis of silver-NHC complexes and subsequent reaction with [RuCl2(p-cymene)](2) in dichloromethane (DCM) under argon atmosphere. The new ruthenium(ii)-NHC complexes were applied to transfer hydrogenation of ketone derivatives using 2-propanol as a hydrogen source and KOH as a co-catalyst. The results show that the corresponding alcohols could be obtained in good yield with high catalyst activity (up to 76%) under mild conditions. All new compounds were characterized by spectroscopic and analytical methods. The antibacterial activities of the corresponding ruthenium(ii)-NHC complexes 4a-i were tested against positive and negative bacteria using the agar dilution procedure and their IC50 values have been determined. A cytotoxicity study of the ruthenium(ii)-NHC complexes 4 was performed against the two human cancer cell lines MDA-MB-231 and MCF-7. In addition, the scavenging activity of the synthesized complexes for the DPPH radical was also determined.eninfo:eu-repo/semantics/closedAccessHeterocyclic Carbene ComplexesAsymmetric Transfer HydrogenationMetal-ComplexesStructural-CharacterizationOlefin MetathesisAryl ChloridesSystemKetonesActivationCisplatinArticle44145309532310.1039/d0nj00311e2-s2.0-85083039285Q2WOS:000524498200015Q2