Vardi, NigarParlakpinar, HakanAksungur, ZeynepCoskun, Ebru IncıPolat, SeyhanYıldız, AzibeOzhan, Onural2026-04-042026-04-0420232147-0634https://doi.org/10.5455/medscience.2023.09.184https://search.trdizin.gov.tr/tr/yayin/detay/1261418https://hdl.handle.net/11616/107331Ovarian torsion is a gynecological emergency characterized by ovarian ischemic damage. This study aimed to investigate the possible protective effects of dexpanthenol (DEX)-an antioxidant molecule-against ovarian ischemic damage in rats. The rats were simple randomly grouped into (1) Sham group (n=8); (2) Ischemia (I) group (n=8) (2 hours of I in ovaries); (3) DEX+I group (n=8) (500 mg/kg DEX administration 30 minutes before 2 hours of I.) The removed ovaries were examined histopathologically and biochemically. In the DEX+I group, necrosis-pycnosis severity was significantly reduced compared to the I group; but congestion-hemorrhage severity was similar. In the I group, malondialdehyde (MDA) and total oxidant status (TOS) levels were slightly increased, and glutathione (GSH) levels were significantly decreased compared to the Sham group. In the DEX+I group, MDA and TOS levels were slightly reduced and GSH levels were slightly increased compared to the I group. DEX prevents ischemic damage in rat ovaries via an antioxidant effect. Further research is needed to support our findings.eninfo:eu-repo/semantics/openAccessKadın Hastalıkları ve DoğumBiyoteknoloji ve Uygulamalı MikrobiyolojiBiyokimya ve Moleküler BiyolojiArticle1241213121710.5455/medscience.2023.09.1841261418