Ozturk, MehmetSigirci, AhmetUnlu, Serkan2024-08-042024-08-0420160899-70711873-4499https://doi.org/10.1016/j.clinimag.2016.09.005https://hdl.handle.net/11616/97514Purpose: This study aimed to determine differences according to age groups and gender in the parameters of aqueductal cerebrospinal fluid (CSF) flow in childhood using phase-contrast cine magnetic resonance imaging (MRI) method. Materials and methods: This prospective study included 47 boys and 36 girls for a total of 83 healthy children. The cases were divided into three groups depending on age as infants (1-12 months), children (12-120 months), and adolescents (120-204 months). To quantitatively evaluate CSF flow, images in the transverse plane were taken at the cerebral aqueduct level using the phase-contrast MR angiography technique in a 1.5-T MR unit. Peak and average velocity (cm/s), cranial direction, caudal direction and net volume (ml), and aqueduct area (mm2) were calculated. To assess differences between the groups, a one-way analysis of variance and least significant difference tests were used. Results: A statistically significant difference was determined between children and adolescents in peak velocity and caudal direction volume (P=.012 and P=.039, respectively) and between infants and children in cranial direction volume (P=.036). Peak velocity, cranial direction, and net volume were higher in boys (P=.050, P=.016, and P=.029, respectively). There were no differences by age and gender in the aqueduct area. Conclusion: In conclusion, this study determined the normal values for the CSF flow parameters of velocity, volume, and aqueduct area using phase-contrast MRI in healthy children. Velocity and volume parameters varied according to age and sex and were not affected in the aqueductal area. Published by Elsevier Inc.eninfo:eu-repo/semantics/closedAccessPhase-contrast cine MRICerebrospinal fluidNormal pediatric casesCerebral aqueductArticle406128612902768499610.1016/j.clinimag.2016.09.0052-s2.0-84988710081Q2WOS:000387529900036Q4