Seven, Pinar TatliBaykalir, Burcu GulSeven, IsmailAk, Tuba ParlakBasak, NeseGulluoglu, Hakan2024-08-042024-08-0420181300-0128https://doi.org/10.3906/vet-1710-70https://search.trdizin.gov.tr/yayin/detay/356712https://hdl.handle.net/11616/92513Thirty-six Sprague Dawley male rats were housed in individual cages and randomly divided into six groups: control, copper sulfate (Cu; 500 ppm body weight (BW)/day), flunixin meglumine (FM; 2.2 ppm BW/day), chrysin (chrysin; 50 ppm BW/day), copper sulfate + FM (Cu + FM; 500 ppm BW/day of copper sulfate and 2.2 ppm BW/day of FM), and copper sulfate + chrysin (Cu + Chrysin; 500 ppm BW/day of copper sulfate and 50 ppm BW/day of chrysin). Feed intake (FI) in the Cu + Chrysin group significantly increased in comparison with that of the Cu group (P < 0.01). Cu excess significantly increased malondialdehyde, indicating oxidative stress. Chrysin and FM administration significantly decreased malondialdehyde levels and increased the superoxide dismutase and catalase activities in the liver and kidney tissues (P < 0.001). Serum TNF-a levels were significantly lower in the Cu + FM and Cu + Chrysin groups in comparison to the Cu group (P < 0.001). It was seen that FM and chrysin treatments alleviated degeneration, necrosis, and apoptosis in the liver and kidney tissues of the Cu-treated rats. Chrysin appeared to ameliorate the adverse effects on FI and liver and kidney tissues by scavenging where the free radicals are located and increasing the activity of antioxidants.eninfo:eu-repo/semantics/openAccessAntioxidant statusbody weight changechrysincopperflunixin megluminehistological changesArticle42537638710.3906/vet-1710-702-s2.0-85055868517Q3356712WOS:000447163600002Q3