Kizilay A.Kalcio?lu M.T.Ozu?urlu F.Ozyurt H.Alada? I.Ozturan O.Akyol O.2024-08-042024-08-0420071300-7475https://hdl.handle.net/11616/91289OBJECTIVES: We determined serum nitric oxide (NO) levels in patients with head and neck squamous cell carcinoma (SCC) and sought correlations with TNM staging, tumor localization, and tumor grade. PATIENTS AND METHODS: Serum samples were obtained from 36 patients (mean age 63 years; range 37 to 80 years) with head and neck SCC prior to treatment and from 20 healthy individuals (mean age 56 years; range 30 to 72 years) as controls. Tumor staging was based on the criteria of the American Joint Committee of Cancer staging system in 2002. Thirteen patients had stage I-II, and 23 patients had stage III-IV tumors and all had well- or moderately-differentiated SCC (grade 1-2). Serum NO levels were analyzed by a spectrophotometric method based on the determination of total nitrite levels in serum and compared between the patient and control groups. RESULTS: The mean serum NO levels were 20.08+/-1.40 micromol/l and 13.57+/-0.99 micromol/l in cancer patients and controls, respectively (p=0.001). There were no correlations between NO levels and age, sex, tumor stage, localization, and histological grade. CONCLUSION: These data suggest that head and neck SCC is associated with increased serum NO levels, which may play a role in tumor growth.eninfo:eu-repo/semantics/closedAccessnitric oxidetumor markeradultagedarticlebloodcancer stagingcase control studyevaluationfemalehead and neck tumorhumanmalemiddle agedpathologyprediction and forecastingsquamous cell carcinomaAdultAgedAged, 80 and overCarcinoma, Squamous CellCase-Control StudiesFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedNeoplasm StagingNitric OxidePredictive Value of TestsTumor Markers, BiologicalArticle173148151178735052-s2.0-34948815594N/A