Ulu, Oznur Dogan2024-08-042024-08-0420231857-55521857-5625https://doi.org/10.20450/mjcce.2023.2589https://hdl.handle.net/11616/101348In this study, a 1,3-dioxane functionalized benzimidazole salt and its Ag-complex were synthe-sized. The prepared compounds were structurally verified by several spectroscopic techniques including 1H NMR, 13C NMR, FT-IR, LC-MS, and C, H, N analysis. Compounds were evaluated for their in vitro antioxidant activity. The salts and their Ag-NHC complexes were further evaluated for their in vitro anti-cancer activities against HCT-116 human colon cancer cells. The results showed that complex 2 exhibited high activity (4.1 times) against the cancer cell lines studied when compared to the reference drug cispla-tin. Stability studies demonstrated that these compounds are stable in aqueous and organic solutions.eninfo:eu-repo/semantics/openAccesssilver complexesN-heterocyclic carbenebenzimidazole13-dioxaneantioxidant and anticancer activityArticle42110.20450/mjcce.2023.25892-s2.0-85159141164Q4WOS:000985390100001Q3