Senol M.Fireman P.2024-08-042024-08-0419971300-4301https://hdl.handle.net/11616/91199Skin mast cells play an important role in cutaneous inflammation, especially IgE-mediated, complement-mediated, and T cell-mediated delayed type hypersensitivity reactions. They can synthesize and release various preformed and newly formed mediators that are important in the pathobiology of certain diseases such as urticaria, mastocytosis, atopic dermatitis, contact dermatitis, bullous pemphigoid, scleroderma, psoriasis, and parasitic skin infections. Reading this article will reinforce the reader's knowledge of the recent concepts on human cutaneous mast cells. Their origin, morphology, distribution, heterogeneity, function, activation, and mediators are included in the subject. Interactions of mast cells with their microenvironment and the other cells, and their role in some pathobiologic situations are briefly outlined.eninfo:eu-repo/semantics/closedAccessanogenital seborrheic keratosesseborrheic keratosisReview Article61-263692-s2.0-0030931396N/A