Erdemli, ZeynepErdemli, Mehmet ErmanGul, MehmetAltinoz, EyupGul, SemirKocaman, GulhanKustepe, Elif Kayhan2024-08-042024-08-0420212008-38662008-3874https://doi.org/10.22038/ijbms.2021.55875.12499https://hdl.handle.net/11616/100000Objective(s): The present study aimed to investigate the effects of periodontitis on kidneys and the protective role of crocin in periodontitis-induced kidney damage. Materials and Methods: Ethics committee approval was obtained and 30 Wistar rats were randomly divided into 3 groups of 10 rats: Control (C), Periodontitis (P), and Periodontitis + Crocin (P + Cr). After the treatments, rat kidney tissues were incised under anesthesia and blood samples were collected. Biochemical and histopathological analyses were conducted on the samples. Results: Malondialdehyde (MDA), total oxidant status (TOS), and oxidative stress index (OSI) increased in P group rat kidney tissues; urea, creatinine, Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin 1 beta (IL-1 beta) levels increased in the serum; glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) levels were reduced in rat kidney tissues, and renal histopathology deteriorated. In the P + Cr group, we observed improvements in biochemical and histopathological parameters when compared with the P group. Conclusion: Periodontitis (P) led to deterioration in oxidative stress parameters and histopathology by increasing the oxidants in kidney tissue. P also led to inflammation in the blood of the rats. Periodontitis + Crocin (P + Cr) administration alleviated the effects of P due to powerful antioxidant anti-inflammatory properties. Cr could be employed as a protective agent in P-induced inflammation and oxidative damage.eninfo:eu-repo/semantics/closedAccessCrocinInflammationKidney damageOxidative stressPeriodontitisRatArticle2468258323463096010.22038/ijbms.2021.55875.124992-s2.0-85108515758Q2WOS:000657429800014Q3