Okmen, Zeynep HazirogluCeliksoy, Mehmet HalilTopal, Erdem2024-08-042024-08-0420212151-321X2151-3228https://doi.org/10.1089/ped.2021.0161https://hdl.handle.net/11616/100398Background: Allergic rhinitis (AR) is a chronic disease that is becoming increasingly common worldwide and has a negative impact on school performance, work performance, and quality of life. The aim of this study was to investigate the effect of vitamin D on the symptoms of AR in children. Methods: Serum vitamin D levels of children with AR and age-matched healthy controls were compared using the high-pressure liquid chromatography method. The relationship between serum vitamin D levels and symptoms and severity of AR was then examined. Results: The study included 137 patients diagnosed with AR (76 males, 61 females; median age: 11 years). Serum vitamin D levels were lower in the patient group than in the control group (P = 0.001), lower in all aeroallergen groups (mites, pollen, and multiple inhalants) than in the healthy control group (P = 0.001), and lower in both the perennial AR group and the seasonal AR group than in the control group (P = 0.001). Spearman correlation analysis showed that there was no correlation between symptom score and vitamin D level (r(s) = -0.099; P = 0.25). Conclusions: We found no correlation between serum vitamin D level and symptoms and severity of AR. Serum vitamin D levels were lower in children with AR than in healthy children.eninfo:eu-repo/semantics/openAccessallergic rhinitischildrenvitamin Dsymptom scoreArticle3441321403495824510.1089/ped.2021.01612-s2.0-85122370362Q3WOS:000975004300002Q4