Metan, GokhanCuha, Mervenur DemirHazirolan, GulsenDizman, Gulcin TelliTanriverdi, Elif SerenOtlu, BarisTas, Zahit2024-08-042024-08-0420222196-5226https://doi.org/10.3205/dgkh000418https://hdl.handle.net/11616/104465We investigated the change in the epidemiology of nosocomial blood-stream infections (BSIs) caused by multidrug-resistant bacteria during Coronavirus Disease (COVID-19) and antibiotic consumption rates at a pandemic hospital and at the Oncology Hospital which operated as COVID-19-free on the same university campus. Significant increases in the infection density rate (IDRs) of BSIs caused by carbapenem-resistant Acinetobacter baumannii (CRAB) and ampicillin-resistant Enterococcus faecium (ARE) were detected at the pandemic hospital, whereas car-bapenem-resistant Klebsiella pneumoniae BSIs were increased at the non-pandemic Oncology Hospital. Pulsed field gel electrophoresis showed a polyclonal outbreak of CRAB in COVID-19 intensive care units. Antibiotic consumption rates were increased for almost all antibiotics, and was most significant for meropenem at both of the hospitals. In-creased IDRs of CRAB and ARE BSIs as well as an increased consump-tion rate of broad-spectrum antibiotics emphasize the importance of a multimodal infection prevention strategy combined with an active anti-biotic stewardship program.eninfo:eu-repo/semantics/closedAccessCOVID-19SARS-CoV-2antibacterial resistancebacteremiaantibiotic consumptionArticle173615738210.3205/dgkh000418WOS:000849220000001N/A