Yildiz, SevlerEmir, Burcu SirlierKilicaslan, Asli KazganKurt, OsmanUgur, KerimSehlikoglu, SeymaAtmaca, Murad2026-04-042026-04-0420251478-99491478-9957https://doi.org/10.1080/14789949.2024.2429663https://hdl.handle.net/11616/109229The role of inflammation in the etiology of psychotic disorders (PD) is well-established. This study aimed to identify inflammation parameters in patients diagnosed with PD, assess their potential as biomarkers, and examine their relationship with criminal behavior. This retrospective study comprised three groups: 530 patients diagnosed with PD who had committed crimes (offenders with PD), 530 patients with PD who had not committed crimes (non-offenders with PD), and 530 healthy controls, totaling 1,590 participants. Routine hematological tests were used to measure neutrophil, lymphocyte, monocyte, and platelet counts, high-density lipoprotein (HDL), systemic inflammatory response index (SIRI), systemic immune-inflammatory index (SII), and neutrophil/HDL (NHR), lymphocyte/HDL, platelet/HDL (PHR), and monocyte/HDL (MHR) ratios. Offenders with PD exhibited significantly higher levels of SII, SIRI, PHR, NHR, LHR, neutrophils, and monocytes compared to non-offenders with PD and healthy controls (p < 0.001). The criminal group had lower HDL and lymphocyte levels than the remaining two groups (p < 0.001). Among those treated in forensic psychiatry units, patients with two or more treatments showed significantly higher SIRI values compared to those with only one treatment (p = 0.045). Non-offenders with PD had higher platelet values than the remaining two groups (p < 0.001). This study underscores the role of systemic inflammation in the pathophysiology of psychotic disorders through a comparison of patients who have and have not committed crimes, highlighting the relationship between inflammation and lipid metabolism. Further research is required to clarify these findings.eninfo:eu-repo/semantics/closedAccessPsychotic disorderSIRISIIinflammationHDLhemogramArticle36327529210.1080/14789949.2024.24296632-s2.0-85210144245Q3WOS:001363763600001Q30000-0002-0312-04760000-0003-4164-36110000-0002-9512-713X0000-0002-3389-57900000-0002-3131-6564