Toy V.E.Dundar S.Bozoglan A.2024-08-042024-08-0420202212-4268https://doi.org/10.1016/j.jobcr.2020.06.006https://hdl.handle.net/11616/91961Objective: The aim of this study was to histologically examine the effects of a nonsteroidal anti-inflammatory drug, namely diclofenac sodium (DCS), on the extent of the bone–implant contact (BIC) of titanium implants after four weeks of osseointegration period in a rodent model. Material & methods: Fourteen female Sprague-Dawley rats were divided into two groups: the control (n = 7) and experimental (DCS) groups. Fourteen machine-surfaced titanium implants were placed in the right tibial bones of the rats. The DCS (2 mg/kg) was administered by means of oral gavage to the experimental group for 14 days after four weeks of osseointegration. No medication was administered to the control group throughout the six-week study period. At the end of the study, the rodents were sacrificed and block sections were obtained for histologic evaluation. Results: The mean BIC ratios for the control and DCS groups were 64.15 ± 6.31% and 61.10 ± 6.08%, respectively. No statistically significant difference in terms of the BIC ratios was found between the two groups. Conclusion: The results of this study demonstrate that DCS did not impair the BIC of the implants after four weeks of osseointegration. © 2020 Craniofacial Research Foundationeninfo:eu-repo/semantics/openAccessBone implant connectionDiclofenac sodiumNonsteroidal anti-inflammatory drugOsseointegrationArticle10433333610.1016/j.jobcr.2020.06.0062-s2.0-85087911576Q2