Melekoğlu, RaufÇiftçi, OsmanÇetin, AslıBaşak, NeşeÇelik, Ebru2017-04-172017-04-172016Melekoğlu, R. Çiftçi, O. Çetin, A. Başak, N. Çelik, E. (2016). The beneficial effects of Montelukast against 2 3 7 8 tetrachlorodibenzo p dioxin toxicity in female reproductive system in rats . Acta Cir Bras. 31 (8) - 557-563.1678-2674http://dx.doi.org/10.1590/S0102-865020160080000009https://hdl.handle.net/11616/6673PURPOSE: To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis. METHODS: Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed. RESULTS: The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment. CONCLUSION: The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.eninfo:eu-repo/semantics/openAccessTetrachlorodibenzodioxinOxidative StressLeukotriene AntagonistsOvaryUterusArticle318557563