Doganay S.Er H.Tasar A.Gürses I.2024-08-042024-08-0420050165-5701https://doi.org/10.1007/s10792-006-0006-6https://hdl.handle.net/11616/90517PURPOSE: To report surgical excision, cryotherapy, autologous conjunctival-limbal transplantation and topical mitomycin C (MMC) in the patient with extensive conjunctival-corneal intraepithelial neoplasia. METHODS: Case report and literature review. RESULTS: A 75-year-old woman was referred to our department with the diagnosis of conjunctival-corneal neoplasia. Slit-lamp microscopic examination revealed an extensive papilliform tumoral mass invading the limbus at 360-degrees, and bulbar conjunctiva and cornea. Visual acuity was finger counting from 2 m in the right eye and 20/20 in the left eye. We performed total surgical excision, cryotherapy and autologous conjunctival-limbal transplantation in the right eye. Mitomycin-C 0.02% eye drops four times a day were prescribed for 4 weeks after the surgery. After the treatment, the visual acuity increased to 0.7 in the right eye. Corneal epithelium completely healed within 1 week after the surgery. No corneal epithelium-related problem or neoplasia recurrence were noted during the 2-year follow-up period. CONCLUSIONS: This technique may be useful in reconstruction of eyes with extensive neoplastic involvement of the conjunctiva, limbus, and cornea. In addition, mitomycin C drops may be useful in preventing postoperative recurrence of conjunctival-corneal intraepithelial neoplasia.eninfo:eu-repo/semantics/closedAccessantineoplastic antibioticmitomycinagedarticleautotransplantationcarcinoma in situcase reportconjunctiva tumorcornea diseasecornea epitheliumcornea limbuscornea transplantationcryotherapyfemalefollow uphumanmethodologypathologyAgedAntibiotics, AntineoplasticCarcinoma in SituConjunctival NeoplasmsCorneal DiseasesCorneal TransplantationCryotherapyEpithelium, CornealFemaleFollow-Up StudiesHumansLimbus CorneaeMitomycinTransplantation, AutologousMLCSMLOWNArticle261-253571677956710.1007/s10792-006-0006-62-s2.0-33750741998Q2