Tuerkcueoglu, I.Tezcan, S.Kaygusuz, G.Atabekoglu, C. SomerOrtac, F.Guengoer, M.Kankaya, D.2024-08-042024-08-0420070392-2936https://hdl.handle.net/11616/104568Purpose: The aim of this study was to determine the role of p53, Bcl-2 and Ki-67 expression in the carcinogenesis of cervical carcinoma and aggressiveness of cervical intraepithelial neoplasia (CIN). Methods: The pathology specimens of 63 patients with a diagnosis of normal squamous epithelium (22 cases), CIN I (14), CIN II (5), CIN III (8) and squamous cell carcinoma (14) were evaluated immunohistochemically for the expression of p53, Bcl-2 and Ki-67 in paraffin sections. Results: The expression of p53 and Ki-67 increased proportionally to the grade of CIN and cervical cancer, but only the increase of p53 expression was statistically significant (p = 0.002). There was no significant correlation between Bcl-2 expression and premalignant and malignant cervical lesions. Conclusion: p53 expression may have a role in the carcinogenesis of squamous cell cervical carcinoma whereas Bcl-2 expression has no role. Ki-67 expression can not be used in determining the aggressiveness of CIN lesions.eninfo:eu-repo/semantics/closedAccesscervical intraepithelial neoplasiacervical cancerp53Bcl-2Ki-67Article28429029317713095WOS:000248192500009Q4