Turker, FerhatGurses, CanbolatCelepci, Duygu BarutAktas, AydinAtes, BurhanGok, Yetkin2024-08-042024-08-0420190365-62331521-4184https://doi.org/10.1002/ardp.201900187https://hdl.handle.net/11616/98991A series of the morpholine-liganded palladium(II) complexes (1a-e) bearing N-heterocyclic carbene (NHC) functionalized by benzonitrile were synthesized. These complexes were synthesized from (NHC)Pd(II)(pyridine) complexes (PEPPSI) and morpholine. The new complexes were fully characterized by using H-1 NMR, C-13 NMR, Fourier-transform infrared spectroscopy, and elemental analysis techniques. Single-crystal X-ray diffraction was used to determine the structure of a derivative. The DNA-binding studies of the new (NHC)Pd(II)morpholine complexes were examined using the pBR322 plasmid. The 2,4,6-trimethylbenzyl derivative compound has the most DNA binding activity. In addition, for the 3-methylbenzyl derivative compound, oxidation effects were observed at concentrations higher than 100 mu g/ml. Also, the molecular and crystal structures of the complex 3-methylbenzyl derivative compound were recorded by using a single-crystal X-ray diffraction method.eninfo:eu-repo/semantics/closedAccessDNA bindingN-heterocyclic carbenestructure elucidationsubstituent effectsynthesisArticle352123158376310.1002/ardp.2019001872-s2.0-85073960768Q2WOS:000491199200001Q2