Yilmaz, Zeynep BurcinMemisoglu, FundaHidayet, EmineKuku, IrfanErkurt, Mehmet AliKaya, EminBerber, Ilhami2026-04-042026-04-0420250041-13451873-2623https://doi.org/10.1016/j.transproceed.2025.05.018https://hdl.handle.net/11616/109393Introduction and Purpose. Cytomegalovirus (CMV) infection is a prevalent complication, affecting 30% to 50% of patients following Allogeneic Hematopoietic Stem Cell Transplantation (allo-AHCT). This study aims to investigate the risk factors contributing to CMV infection development. Materials and Methods. A retrospective analysis was performed on 196 patients with hematological malignancies who underwent allo-HSCT in the Stem Cell Transplantation Unit of Inonu University Faculty of Medicine over a 5-year period. Propensity scores were calculated by matching 1:1 for gender and age variables in individuals with CMV infection and in the control group. Results. Of the 196 patients included in the study, 75 (38.3 %) were female and 121 (61.7 %) were male. According to univariate analysis, CMV infection was seen more frequently in ALL patients than in AML patients (p = .012), while the conditioning regimen (p = 1) did not affect the outcome in terms of risk. Blood cyclosporine levels measured simultaneously with CMV positivity were significant in terms of risk (p = .006). A significant correlation was found between GvHD and CMV infection (p < .001). According to multivariate analysis, receiving defibrotide for VOD prophylaxis posed a risk for CMV positivity. Conclusion. In our study, only defibrotide prophylaxis was noted as a risk factor in multivariate analysis. While there are ongoing studies for the use of defibrotide in GVHD prophylaxis, more studies are needed to say that it is a definite risk factor for CMV. We believe that focusing on prophylactic treatments used during the transplantation process will be guiding in determining risk factors.eninfo:eu-repo/semantics/closedAccessCmv InfectionReactivationGuidelinesArticle576113311424058156810.1016/j.transproceed.2025.05.0182-s2.0-105009323362Q3WOS:001542004100021Q40000-0002-3285-417X0000-0003-3121-73870000-0002-6950-60130000-0001-8605-84970000-0003-3312-84760000-0001-6126-0816