Oguzturk, HakanCiftci, OsmanTaslidere, AsliTurtay, Muhammet GokhanGurbuz, SukruBasak, NeseFirat, Cemal2024-08-042024-08-0420181018-46191610-2304https://hdl.handle.net/11616/103428One of the flavonoids, Hesperidin might be beneficial in the treatment of burn injuries. In this study, it was aimed to investigate the effect of Hesperidin in the treatment of burn injuries. In this study, 32 male Sprague Dawley rats were randomized to four groups after local burn development: Group I (Control); rats were left to secondary healing without treatment, Group 2 (Bacitracin group); rats were treated with pomade locally (Bacitracin neomycin sulfate), Group 3(Hesperidin) were treated with Hesperidin for 14 days without Bacitracin, and Group 4(Bacitracin+Hesperidin); local pomade treatment and Hesperidin 50 mg/kg were administered by gastric gavage once a day for 14 days. Skin biopsies and blood samples were collected on days 3, 7,14 relative to burn induction. IL-1 beta and TNF-alpha studies from blood samples and histopathological inspections from tissue biopsies were performed. In Hesperidin + Bacitracin group, 3rd, 7th and 14th days significant reduction in necrosis in the epidermis and dermis, in the 3rd and 14th days little mononuclear cell infiltration that were detected. In this group, on day 14, mononuclear cell infiltration decreased significantly and fairly small amount of vascular congestion was observed on day 7. On day 14 of Hesperidin+Bacitracin group, no congestion or hemorrhage was observed. According to histopathological inspection, it was observed that Hesperidin is effective in burn injury treatment but the best results were observed in Hesperidin+Bacitracin group. It was detected that the most significant decrease in IL-1 beta and TNF-alpha levels in time was in Hesperidin+Bacitracin group. In conclusion, Hesperidin was effective on burn wound healing. Moreover, the effect could be amplified when combined with topical antibiotics in the early stage of burn wound healing.eninfo:eu-repo/semantics/closedAccessBurnHesperidinExperimentalArticle27854465454WOS:000444528000031Q4