Turhan, Duygu Ozhan2024-08-042024-08-0420232619-9149https://doi.org/10.18016/ksutarimdoga.vi.1028753https://search.trdizin.gov.tr/yayin/detay/1159340https://hdl.handle.net/11616/92905In this study, the effects of diclofenac sodium (DKFS), used in medicine and veterinary medicine to control pain and inflammation, on zebrafish embryos and larvae were evaluated. Embryos were exposed to 0.21-5.33 mg L-1 DCFS for 96 hours and the survival rates, heart rate, hatching rates and body malformations of these individuals were determined. LC50, EC50 and teratogenic index (TI) values were calculated as 1.55 and 0.81, 1.91, respectively. DKFS is teratogenic for zebrafish embryos based on the calculated TI value. DKFS at concentrations of 0.47 mg L-1 and higher caused pericardial edema, yolk sac edema, tail malformation and spinal curvature in zebrafish. The most common malformations were determined as pericardial and yolk sac edema. At concentrations of 0.7 mg L-1 and higher, it caused significant inhibition in the length and heart rate of zebrafish larvae. It has been shown that DKFS at concentrations of 2.37 mg L-1 and higher reduced the hatching rate of zebrafish below 50%. These results show that DKFS causes adverse effects on zebrafish development and may adversely affect the aquatic ecosystem if it enters the aquatic environment.eninfo:eu-repo/semantics/openAccessDiclofenac sodiumZebrafish embryo testToxicityArticle26118319110.18016/ksutarimdoga.vi.10287531159340WOS:000933728300021Q4