Tanriverdi, ZubeydeMeteroglu, FatihYuce, HandeSenyigit, AbdurrahmanIscan, MumtazUnuvar, Songul2024-08-042024-08-0420210960-32711477-0903https://doi.org/10.1177/09603271211017324https://hdl.handle.net/11616/99929Introduction: Malignant pleural mesothelioma (MPM) is a malignant tumor that is associated mostly with asbestos exposure. The present study was to evaluates the diagnostic value of neopterin, periostin, YKL-40, Tenascin-C (TNC), and Indolamine 2,3-dioxygenase (IDO) as noninvasive markers of malign pleural mesothelioma. Methods: Included in the study were 30 patients diagnosed with malign pleural mesothelioma, and 25 people as a control group. Biomarker levels were determined using an enzyme immunoassay . A Mann-Whitney U test and Spearman correlation methods were used for the statistical analysis. Results: All evaluated biomarkers were found to be significantly higher in the MPM group than in the control group (p < 0.05). There was no effect of such variables as gender, age or MPMsubtype on the parameters (p > 0.05) in the patient group. All biomarkers were positively correlated with each other (p < 0.001). Conclusions: The current non-invasive biomarkers that can be used in the diagnosis of MPM yielded significant results and can make important contributions to the early diagnosis of MPM.eninfo:eu-repo/semantics/openAccessAsbestosmalign pleural mesotheliomaYKL-40tenascin-CIDOneopterinperiostinArticle4011181718243399829910.1177/096032712110173242-s2.0-85105944105Q2WOS:000652298600001Q3