Cicek, BetulHacimuftuoglu, AhmetYeni, YesimKuzucu, MehmetGenc, SidikaCetin, AhmetYavuz, Emre2024-08-042024-08-0420241382-66891872-7077https://doi.org/10.1016/j.etap.2024.104417https://hdl.handle.net/11616/102444The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO2) for 21 days. 10 mu g/g AuNPs, 1.6 g/kg CS, and 10 mu g/g CS-AuNPs were administered orally simultaneously with 10 mg/ kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-alpha and IL-1 beta levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments.eninfo:eu-repo/semantics/closedAccessAuNPsArsenicCynara scolymusNeurotoxicityD1RD2RArticle1073849387910.1016/j.etap.2024.104417WOS:001223389200001N/A