Taskin, Irmak IcenGurbuz, SevimIcen, Mehmet SaitDerin, Dilek CamFindik, Fatih Mehmet2024-08-042024-08-0420230104-42301806-9282https://doi.org/10.1590/1806-9282.20230360https://hdl.handle.net/11616/101520OBJECTIVE: This study aimed to investigate the expression levels of sirtuin 2 and sirtuin 7 in the placenta accreta spectrum to reveal their role in its pathogenesis.METHODS: A total of 30 placenta accreta spectrum, 20 placenta previa, and 30 controls were experienced. The sirtuin 2 and sirtuin 7 expression levels in the placentas of these groups were determined by Western blot. sirtuin 2 and sirtuin 7 serum levels in the maternal and fetal cord blood were examined by enzyme-linked immunosorbent assay.RESULTS: It was found that sirtuin 7 in placenta accreta spectrum was significantly lower in the placenta compared to the control and placenta previa groups (p<0.05). However, a significant difference was not observed between the sirtuin 2 and sirtuin 7 levels in the maternal and fetal cord serum samples of those three groups (p>0.05).CONCLUSION: Sirtuin 7 may play an important role in the formation of placenta accreta spectrum. The effect of decreased expression of sirtuin 7 might be tissue-dependent in the placenta accreta spectrum and needs to be investigated further.eninfo:eu-repo/semantics/openAccessEpithelial-mesenchymal transitionPlacenta accretaPlacenta previaSirtuin 2SirtuinsArticle6983758599510.1590/1806-9282.202303602-s2.0-85168251589Q3WOS:001051569300001Q2