Tecellioglu, Fahriye SecilAkpolat, NusretSahin, Nurhan2024-08-042024-08-0420212363-83972363-8400https://doi.org/10.1007/s40944-020-00492-7https://hdl.handle.net/11616/99769Backgrounds Matrix metalloproteinases (MMP) and fascin-1 play roles in epithelial-mesenchymal transition and tumour invasion. Aims This study was performed to investigate the relationships of fascin-1 and MMP-9 expression with prognostic parameters in endometrioid-type endometrial carcinoma (EEC). Methods A total of 100 cases of EEC were included in the study. Tissues were stained with antibodies against fascin-1 and MMP-9. The relationships between the immunohistochemical findings and clinicopathological prognostic parameters of EEC were examined. Results Tumour diameter was significantly related to lymphovascular invasion, FIGO stage and FIGO grade (p < 0.05). A tumour size > 2 cm was associated with a poor prognosis. The staining score for fascin-1 was <= 5 in 81 cases and > 5 in 19 cases (p > 0.05), and that for MMP-9 was <= 5 in 39 cases and > 5 in 61 cases (p > 0.05). Neither fascin-1 nor MMP-9 expression was significantly related to any of the clinicopathological parameters examined. Conclusion There were no significant relationships of fascin-1 and MMP-9 expression with the clinicopathological parameters of EEC. The results of this study suggested that these molecules do not contribute to the clinical behaviour of EECs. A tumour size > 2 cm is associated with a poor prognosis in EEC patients. To verify these results, more studies are needed with larger patient groups.eninfo:eu-repo/semantics/closedAccessEndometrial carcinomaEndometriumFascin-1MMP-9PrognosisArticle19110.1007/s40944-020-00492-72-s2.0-85100992449Q4WOS:000617130500001N/A